In our view, the fact that Teneobio's VH binders are fully human makes them a better option than camelid VHH single domain antibodies." Their advantageous smaller in size, and superior developability relative to standard scFv’s make them ideal for CAR T-cell products.”Įric Ostertag, CEO of Poseida, added, "We have evaluated a large number of binding technologies for use in our CAR-T platforms and view single domain antibodies as one of the most superior. They have demonstrated both in vivo specificity and robust efficacy. “UniDabs have been preclinically and clinically validated as excellent human single domain antibody targeting moieties of CAR T-cells. “We are excited that Poseida has exercised multiple commercial license options on UniDabs to create the next generation of cell therapies," said Omid Vafa, CBO of Teneobio. Teneobio would also receive royalties on worldwide net sales of each CAR-T therapy. receives commercial licensing fees for these milestones and is eligible to receive future research, development and regulatory milestone payments per UniDab candidate, with total potential earnings of over $250 million for CAR-T therapies developed by Poseida. Poseida would have exclusive global licensing rights for the clinical development and commercialization of specific UniDabs for CAR cell therapies. Under the terms of that agreement, Teneobio would generate multiple UniDab product candidates using its proprietary UniRat® transgenic human antibody ‘heavy-chain only’ rodent platform and its state-of-the-art sequence-based discovery engine, TeneoSeek. This announcement follows the expansion of a commercial license agreement between the companies that was announced in August of 2018. Poseida will apply licensed UniDab binders, which possess significant advantages over traditional single chain variable antibody fragment (scFv) binders, to develop its next generation CAR-T therapies. 23, 2020 (GLOBE NEWSWIRE) - Teneobio, Inc., a clinical stage next generation, multi-specific antibody therapeutics company, announced today that in 2020, Poseida exercised four options to commercial licenses for Teneobio human heavy chain only domain antibodies, UniDabs®, to develop novel CAR T therapies. Otherwise, nothing gets done.NEWARK, Calif., Nov. What I have to do on set is make sure the machine moves fast, but the moment the camera rolls, you go into that quiet mode. That’s an important aspect of what the assistant director is. “It looks preposterous, but you have to treat it seriously and create an atmosphere on set as if you’re at the theatre, while there’s all this anarchy going on. And then obviously everything is added in post. “So you have him standing on a cliff-edge with a flapping cape, and a guy dressed in wet-weather gear, because it’s freezing, holding up a green ball on the end of a green stick. He had this heavy cape on, and had the wind picked up any more, he would have just turned into a human kite.” “The sequence where Jon meets Drogon, we were filming on a cliff-edge in Northern Ireland, with very high winds, and Kit had this safety rope attached to him, and a harness, because it was so windy. An actor is trying to act quite often with something that isn’t there, so they’re being challenged to emote while looking at a green screen, or a piece of green cloth. “The fans love them, but honestly, they’re very hard to work with. And it’s a tricky one, too,” Endean said. “Whenever a dragon appears, it’s expensive. Head of the assistant director’s department for the show, Charlie Endean, talked to The Verge about everything that needed to go just right for the scene to work, as well as the natural elements that were attempting to send Jon over the edge… literally! In amongst those things to keep the peepers on was the first meeting between Jon Snow and Dany’s dragon, something which was pulled off with aplomb on screen, but behind-the-scenes was much more difficult than you might have guessed. While the fifth episode of the seventh season – titled “Eastwatch” – felt like a bit of a breather between last week’s Dracaras-heavy action and next week’s Night King terror, there was still an awful lot in the episode to get your teeth into.īetween Gilly’s bombshell revelation, to the significance of Arya’s note-finding skills, to the 15 other things you may have missed, Eastwatch kept the narrative action going even while the actual action took the day off. In case you didn’t already know, we here at JOE are big GOT fans.
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